| 54 |
Alnylam Pharmaceuticals Inc. VIR-2218 · Hepatitis D (HDV) (Antiviral)
Infectious Disease RARE |
PH3 |
Mar 2026 slightly early |
70 |
59% |
Dana |
| 55 |
Vir Biotechnology, Inc. tobevibart · Hepatitis D (HDV) (Antiviral)
Infectious Disease RARE |
PH3 |
Mar 2026 slightly early |
70 |
59% |
Open |
| 56 |
ORCA Bio Inc. Orca-T · Acute Lymphoblastic Leukemia (ALL)
Oncology RARE |
NDA/BLA |
Jun 2027 early — Tier 2 timing |
70 |
95% |
Dana |
| 57 |
ORCA Bio Inc. Orca-T · Myelodysplastic Syndrome (MDS)
Oncology RARE |
NDA/BLA |
Jun 2027 early — Tier 2 timing |
70 |
95% |
Dana |
| 58 |
Zealand Pharma A/S Glepaglutide · Short Bowel Syndrome (SBS)
Gastroenterology (Non Inflammatory Bowel Disease) RARE |
PH3 |
Feb 2026 slightly early |
70 |
58% |
Dana |
| 59 |
Zealand Pharma A/S Glepaglutide · Short Bowel Syndrome (SBS)
Gastroenterology (Non Inflammatory Bowel Disease) RARE |
PH3 |
Jun 2026 slightly early |
70 |
58% |
Dana |
| 60 |
Takeda Pharmaceutical Co. Ltd. mezagitamab · Immunoglobulin A (IgA) Nephropathy (Berger's Disease)
Renal RARE |
PH3 |
Mar 2026 slightly early |
69 |
43% |
Dana |
| 61 |
Vertex Pharmaceuticals Incorporated povetacicept · Immunoglobulin A (IgA) Nephropathy (Berger's Disease)
Renal RARE |
PH3 |
Mar 2026 slightly early |
69 |
43% |
Amy |
| 62 |
AstraZeneca PLC Ultomiris · Immunoglobulin A (IgA) Nephropathy (Berger's Disease)
Renal RARE |
PH3 |
Jun 2026 slightly early |
69 |
43% |
Dana |
| 63 |
Vertex Pharmaceuticals Incorporated povetacicept · Immunoglobulin A (IgA) Nephropathy (Berger's Disease)
Renal RARE |
PH3 |
Jun 2026 slightly early |
69 |
43% |
Amy |
| 64 |
Vertex Pharmaceuticals Incorporated povetacicept · Immunoglobulin A (IgA) Nephropathy (Berger's Disease)
Renal RARE |
PH3 |
Jun 2026 slightly early |
69 |
43% |
Amy |
| 65 |
Renibus Therapeutics Inc. RBT-1 · Cardiac Valve Surgery
Cardiovascular |
NDA/BLA |
Apr 2026 SWEET SPOT — ~12 mo to lau |
69 |
46% |
Steve |
| 66 |
Renibus Therapeutics Inc. RBT-1 · Coronary Artery Bypass Graft (CABG)
Cardiovascular |
NDA/BLA |
Apr 2026 SWEET SPOT — ~12 mo to lau |
69 |
46% |
Steve |
| 67 |
Incyte Corporation Monjuvi · Marginal Zone Lymphoma - NHL
Oncology RARE |
PH3 |
Mar 2026 slightly early |
68 |
45% |
Steve |
| 68 |
Evergreen Therapeutics Inc. EG-007 · Uterine (Endometrial) Cancer
Oncology RARE |
PH3 |
Feb 2026 slightly early |
68 |
44% |
Dana |
| 69 |
SynOx Therapeutics Ltd. emactuzumab · Tenosynovial Giant Cell Tumor (TGCT) / Pigmented Villonodular Synovitis (PVNS)
Oncology RARE |
PH3 |
Mar 2026 slightly early |
68 |
44% |
Open |
| 70 |
Tenax Therapeutics, Inc. Simdax · Pulmonary Arterial Hypertension (PAH) and Pulmonary Hypertension (PH)
Cardiovascular RARE |
PH3 |
Jun 2026 slightly early |
68 |
47% |
Open |
| 71 |
Novartis AG zigakibart · Immunoglobulin A (IgA) Nephropathy (Berger's Disease)
Renal RARE |
PH3 |
Jun 2026 slightly early |
68 |
46% |
Dana |
| 72 |
Avidity Biosciences, Inc. Del-zota · Duchenne Muscular Dystrophy (DMD)
Metabolic RARE |
NDA/BLA |
Dec 2026 slightly early |
67 |
35% |
Steve |
| 73 |
Sangamo Therapeutics, Inc. Giroctocogene Fitelparvovec · Hemophilia A
Hematology RARE |
PH3 |
Oct 2026 early — Tier 2 timing |
67 |
77% |
Steve |
| 74 |
Sangamo Therapeutics, Inc. Giroctocogene Fitelparvovec · Hemophilia A
Hematology RARE |
PH3 |
Oct 2026 early — Tier 2 timing |
67 |
77% |
Steve |
| 75 |
Beam Therapeutics Inc. risto-cel · Sickle Cell Disease
Hematology RARE |
NDA/BLA |
Dec 2026 slightly early |
67 |
34% |
Open |
| 76 |
Regeneron Pharmaceuticals, Inc. Veopoz · Paroxysmal Nocturnal Hemoglobinuria (PNH)
Autoimmune/immunology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
66 |
73% |
Dana |
| 77 |
MoonLake Immunotherapeutics AG sonelokimab · Hidradenitis Suppurativa
Dermatology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
65 |
80% |
Open |
| 78 |
AstraZeneca PLC Ultomiris · Transplant-Associated Thrombotic Microangiopathy (TA-TMA)
Hematology |
PH3 |
Jun 2026 slightly early |
65 |
71% |
Dana |
| 79 |
Annexon, Inc. tanruprubart · Guillain-Barré Syndrome
Autoimmune/immunology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
65 |
67% |
Open |
| 80 |
Annexon, Inc. tanruprubart · Guillain-Barré Syndrome
Autoimmune/immunology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
65 |
67% |
Open |
| 81 |
Pharvaris B.V. PHVS416 · Hereditary Angioedema (HAE)
Autoimmune/immunology RARE |
PH3 |
Jun 2026 slightly early |
65 |
66% |
Open |
| 82 |
InnoCare Pharma Ltd. Hibruka · Mantle Cell Lymphoma - NHL
Oncology RARE |
NDA/BLA |
Mar 2026 SWEET SPOT — ~12 mo to lau |
65 |
11% |
Open |
| 83 |
Immix Biopharma, Inc. NXC-201 · Amyloid light-chain (AL) Amyloidosis
Metabolic RARE |
NDA/BLA |
Dec 2026 slightly early |
65 |
25% |
Open |
| 84 |
Wave Life Sciences Ltd. WVE-N531 · Duchenne Muscular Dystrophy (DMD)
Metabolic RARE |
NDA/BLA |
Dec 2026 slightly early |
65 |
25% |
Open |
| 85 |
Organogenesis Inc. ReNu · Osteoarthritis
Rheumatology (Non Autoimmune) |
NDA/BLA |
Jun 2026 SWEET SPOT — ~12 mo to lau |
64 |
40% |
Open |
| 86 |
Regeneron Pharmaceuticals, Inc. cemdisiran · Paroxysmal Nocturnal Hemoglobinuria (PNH)
Autoimmune/immunology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
64 |
75% |
Dana |
| 87 |
BridgeBio Pharma, Inc. BBP-418 · Limb-Girdle Muscular Dystrophy (LGMD)
Metabolic RARE |
PH3 |
Jun 2026 slightly early |
64 |
63% |
Open |
| 88 |
Sarepta Therapeutics, Inc. SRP-9003 · Limb-Girdle Muscular Dystrophy (LGMD)
Metabolic RARE |
NDA/BLA |
May 2027 early — Tier 2 timing |
64 |
62% |
Steve |
| 89 |
Gilead Sciences, Inc. Hepcludex · Hepatitis D (HDV) (Antiviral)
Infectious Disease RARE |
PDUFA |
Jun 2026 launching <6 mo — conversa |
64 |
98% |
Amy |
| 90 |
Intellia Therapeutics, Inc. lonvoguran ziclumeran · Hereditary Angioedema (HAE)
Autoimmune/immunology RARE |
PH3 |
Mar 2027 early — Tier 2 timing |
64 |
61% |
Open |
| 91 |
GC Biopharma Corp. GC-1138A · Glanzmann Thrombasthenia
Hematology RARE |
PH3 |
Jul 2026 early — Tier 2 timing |
64 |
71% |
Open |
| 92 |
Novartis AG ianalumab · Autoimmune Hemolytic Anemia (AIHA)
Hematology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
64 |
71% |
Dana |
| 93 |
Roche Holding AG Piasky · Hemolytic Uremic Syndrome (HUS)
Hematology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
64 |
71% |
Amy |
| 94 |
Roche Holding AG Piasky · Hemolytic Uremic Syndrome (HUS)
Hematology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
64 |
71% |
Amy |
| 95 |
Roche Holding AG Piasky · Hemolytic Uremic Syndrome (HUS)
Hematology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
64 |
71% |
Amy |
| 96 |
Nuvalent, Inc. NVL-655 · Non-Small Cell Lung Cancer (NSCLC)
Oncology |
NDA/BLA |
Jun 2026 SWEET SPOT — ~12 mo to lau |
63 |
54% |
Open |
| 97 |
Ocugen Inc. OCU400 · Retinitis Pigmentosa (RP) (Ophthalmology)
Ophthalmology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
63 |
— |
Steve |
| 98 |
Ocugen Inc. OCU400 · Retinitis Pigmentosa (RP) (Ophthalmology)
Ophthalmology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
63 |
— |
Steve |
| 99 |
Ocugen Inc. OCU400 · Retinitis Pigmentosa (RP) (Ophthalmology)
Ophthalmology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
63 |
— |
Steve |
| 100 |
Travere Therapeutics, Inc. Pegtibatinase · Homocystinuria
Metabolic RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
63 |
60% |
Amy |
| 101 |
Travere Therapeutics, Inc. Pegtibatinase · Homocystinuria
Metabolic RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
63 |
60% |
Amy |
| 102 |
Mithra Pharmaceuticals SA Donesta · Menopause (including Hormone Replacement Therapy [HRT])
Endocrine |
NDA/BLA |
Jul 2026 SWEET SPOT — ~12 mo to lau |
63 |
63% |
Open |
| 103 |
Rezolute, Inc. RZ-358 · Congenital Hyperinsulinism (CHI)
Endocrine RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
63 |
59% |
Dana |
| 104 |
Monopar Therapeutics Inc. ALXN-1840 · Wilson's Disease
Metabolic RARE |
PH3 |
Apr 2026 slightly early |
63 |
58% |
Open |
| 105 |
Sanofi Venglustat · Fabry's Disease
Metabolic RARE |
PH3 |
Jun 2026 slightly early |
63 |
58% |
Amy |
| 106 |
Sanofi Venglustat · Fabry's Disease
Metabolic RARE |
PH3 |
Jun 2026 slightly early |
63 |
58% |
Amy |
| 107 |
Sanofi Venglustat · Gaucher's Disease
Metabolic RARE |
PH3 |
Jun 2026 slightly early |
63 |
58% |
Amy |
| 108 |
Sanofi Venglustat · Gaucher's Disease
Metabolic RARE |
PH3 |
Jun 2026 slightly early |
63 |
58% |
Amy |
| 109 |
Novartis AG ianalumab · Sjogren's Disease
Autoimmune/immunology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
63 |
69% |
Dana |
| 110 |
Novartis AG ianalumab · Sjogren's Disease
Autoimmune/immunology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
63 |
69% |
Dana |
| 111 |
Rafael Holdings, Inc. Trappsol Cyclo · Niemann-Pick Disease Type C
Metabolic RARE |
NDA/BLA |
Jun 2027 early — Tier 2 timing |
63 |
58% |
Open |
| 112 |
Incyte Corporation Opzelura · Hidradenitis Suppurativa
Dermatology RARE |
PH3 |
Apr 2026 slightly early |
63 |
68% |
Steve |
| 113 |
Rafael Holdings, Inc. Trappsol Cyclo · Niemann-Pick Disease Type C
Metabolic RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
63 |
58% |
Open |
| 114 |
Avidity Biosciences, Inc. Delpacibart Braxlosiran · Facioscapulohumeral Muscular Dystrophy (FSHD)
Metabolic RARE |
PH3 |
Mar 2027 early — Tier 2 timing |
63 |
58% |
Steve |
| 115 |
Avidity Biosciences, Inc. Del-desiran · Myotonic Muscular Dystrophy
Metabolic RARE |
PH3 |
Mar 2027 early — Tier 2 timing |
63 |
58% |
Steve |
| 116 |
INmune Bio, Inc. CORDStrom · Epidermolysis Bullosa
Metabolic RARE |
PH3 |
Mar 2027 early — Tier 2 timing |
63 |
58% |
Open |
| 117 |
INmune Bio, Inc. CORDStrom · Epidermolysis Bullosa
Metabolic RARE |
PH3 |
Mar 2027 early — Tier 2 timing |
63 |
58% |
Open |
| 118 |
BridgeBio Pharma, Inc. Encaleret · Hypoparathyroidism
Endocrine RARE |
PH3 |
Mar 2026 slightly early |
63 |
57% |
Open |
| 119 |
Aardvark Therapeutics, Inc. ARD-101 · Prader-Willi Syndrome
Endocrine RARE |
PH3 |
Apr 2026 slightly early |
63 |
57% |
Open |
| 120 |
Novo Nordisk A/S Efruxifermin · Non-Alcoholic Steatohepatitis (NASH)
Endocrine |
PH3 |
Jun 2026 slightly early |
63 |
72% |
Open |
| 121 |
Regeneron Pharmaceuticals, Inc. REGN-7508 · Venous Thromboembolism (VTE)
Hematology |
PH3 |
Jun 2026 slightly early |
63 |
71% |
Dana |
| 122 |
Mineralys Therapeutics, Inc. Lorundrostat · Hypertension (Systemic)
Cardiovascular |
NDA/BLA |
Mar 2026 SWEET SPOT — ~12 mo to lau |
63 |
60% |
Open |
| 123 |
Alpha Tau Medical, Ltd. Alpha DaRT · Skin Cancer - Squamous Cell Carcinoma (SCC)
Oncology |
PH3 |
Mar 2026 slightly early |
63 |
— |
Open |
| 124 |
AstraZeneca PLC Imfinzi · Solid Tumors
Oncology |
PH3 |
Mar 2026 slightly early |
63 |
— |
Dana |
| 125 |
Novo Nordisk A/S coramitug · Hereditary Transthyretin (hATTR) Amyloidosis With Polyneuropathy (Familial Amyloid Polyneuropathy)
Metabolic RARE |
PH3 |
Jun 2026 slightly early |
63 |
25% |
Open |
| 126 |
IDEAYA Biosciences, Inc. IDE196 · Uveal Melanoma
Oncology RARE |
PH3 |
Mar 2026 slightly early |
62 |
46% |
Open |
| 127 |
IDEAYA Biosciences, Inc. IDE196 · Uveal Melanoma
Oncology RARE |
PH3 |
Mar 2026 slightly early |
62 |
46% |
Open |
| 128 |
Roche Holding AG Gazyva · Systemic Lupus Erythematosus (SLE)
Autoimmune/immunology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
62 |
66% |
Amy |
| 129 |
Roche Holding AG Gazyva · Systemic Lupus Erythematosus (SLE)
Autoimmune/immunology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
62 |
66% |
Amy |
| 130 |
Kyverna Therapeutics, Inc. KYV-101 · Neurology - Other
Neurology |
NDA/BLA |
Jun 2026 SWEET SPOT — ~12 mo to lau |
62 |
12% |
Open |
| 131 |
Biogen, Inc. MOR202 · Multiple Myeloma (MM)
Oncology RARE |
NDA/BLA |
Jun 2027 early — Tier 2 timing |
62 |
— |
Dana |
| 132 |
Jazz Pharmaceuticals plc Ziihera · Gastric Cancer
Oncology |
PH3 |
Mar 2026 slightly early |
62 |
49% |
Dana |
| 133 |
Palvella Therapeutics, Inc. Qtorin · Lymphatic Malformation (LM)
Oncology RARE |
PH3 |
Mar 2026 slightly early |
62 |
45% |
Dana |
| 134 |
Palvella Therapeutics, Inc. Qtorin · Lymphatic Malformation (LM)
Oncology RARE |
PH3 |
Mar 2026 slightly early |
62 |
45% |
Dana |
| 135 |
Palvella Therapeutics, Inc. Qtorin · Lymphatic Malformation (LM)
Oncology RARE |
PH3 |
Mar 2026 slightly early |
62 |
45% |
Dana |
| 136 |
Pierre Fabre Tabelecleucel · Hematologic Cancer
Oncology |
PH3 |
Apr 2026 slightly early |
62 |
49% |
Open |
| 137 |
Pierre Fabre Tabelecleucel · Hematologic Cancer
Oncology |
PH3 |
Apr 2026 slightly early |
62 |
49% |
Open |
| 138 |
Jazz Pharmaceuticals plc Ziihera · Gastric Cancer
Oncology |
PH3 |
Jun 2026 slightly early |
62 |
49% |
Dana |
| 139 |
Cogent Biosciences, Inc. bezuclastinib · Gastrointestinal Stromal Tumor (GIST)
Oncology RARE |
PH3 |
Jun 2026 slightly early |
62 |
45% |
Dana |
| 140 |
BioNTech SE DB-1303 · Uterine (Endometrial) Cancer
Oncology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
62 |
— |
Dana |
| 141 |
BioMarin Pharmaceutical Inc. INZ-701 · Metabolic - General
Metabolic |
PH3 |
Jun 2026 slightly early |
62 |
58% |
Amy |
| 142 |
Biogen, Inc. BIIB059 · Systemic Lupus Erythematosus (SLE)
Autoimmune/immunology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
62 |
65% |
Dana |
| 143 |
Johnson & Johnson Bota-vec · Retinitis Pigmentosa (RP) (Ophthalmology)
Ophthalmology RARE |
NDA/BLA |
Jun 2027 early — Tier 2 timing |
62 |
54% |
Steve |
| 144 |
Karyopharm Therapeutics Xpovio · Myelofibrosis (MF)
Oncology RARE |
PH3 |
Mar 2026 slightly early |
62 |
44% |
Steve |
| 145 |
Revolution Medicines, Inc. RMC-6236 · Pancreatic Cancer
Oncology RARE |
PH3 |
Jun 2026 slightly early |
62 |
44% |
Open |
| 146 |
Agenus Inc. balstilimab · Colorectal Cancer (CRC)
Oncology |
NDA/BLA |
Jul 2026 SWEET SPOT — ~12 mo to lau |
62 |
11% |
Dana |
| 147 |
argenx N.V. Vyvgart Hytrulo · Dermatomyositis
Autoimmune/immunology RARE |
PH3 |
Sep 2026 early — Tier 2 timing |
62 |
64% |
Steve |
| 148 |
Actinium Pharmaceuticals, Inc. Iomab-B · Acute Myelogenous Leukemia (AML)
Oncology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
62 |
49% |
Steve |
| 149 |
Merck & Co., Inc. enlicitide decanoate · Dyslipidemia / Hypercholesterolemia
Cardiovascular |
NDA/BLA |
Apr 2026 SWEET SPOT — ~12 mo to lau |
62 |
57% |
Open |
| 150 |
Cellectis SA Lasme-cel · Acute Lymphoblastic Leukemia (ALL)
Oncology RARE |
NDA/BLA |
Dec 2026 slightly early |
62 |
11% |
Open |
| 151 |
GenSight Biologics S.A. Lumevoq · Leber's Hereditary Optic Neuropathy (LHON) (Ophthalmology)
Ophthalmology RARE |
PH3 |
Oct 2026 early — Tier 2 timing |
62 |
53% |
Open |
| 152 |
GenSight Biologics S.A. Lumevoq · Leber's Hereditary Optic Neuropathy (LHON) (Ophthalmology)
Ophthalmology RARE |
PH3 |
Mar 2027 early — Tier 2 timing |
62 |
53% |
Open |
| 153 |
Regeneron Pharmaceuticals, Inc. DB-OTO · Otoferlin Gene-Mediated Hearing Loss
ENT/Dental RARE |
PDUFA |
Jun 2026 launching <6 mo — conversa |
62 |
89% |
Dana |
| 154 |
Idorsia Pharmaceuticals Ltd lucerastat · Fabry's Disease
Metabolic RARE |
PH3 |
Feb 2026 slightly early |
62 |
52% |
Dana |
| 155 |
Idorsia Pharmaceuticals Ltd lucerastat · Fabry's Disease
Metabolic RARE |
PH3 |
Feb 2026 slightly early |
62 |
52% |
Dana |
| 156 |
Idorsia Pharmaceuticals Ltd lucerastat · Fabry's Disease
Metabolic RARE |
PH3 |
May 2026 slightly early |
62 |
52% |
Dana |
| 157 |
Biohaven Ltd. taldefgrobep alfa · Spinal Muscular Atrophy
Metabolic RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
62 |
52% |
Amy |
| 158 |
Gossamer Bio, Inc. seralutinib · Pulmonary Arterial Hypertension (PAH) and Pulmonary Hypertension (PH)
Cardiovascular RARE |
PH3 |
Feb 2026 slightly early |
62 |
51% |
Open |
| 159 |
Gossamer Bio, Inc. seralutinib · Pulmonary Arterial Hypertension (PAH) and Pulmonary Hypertension (PH)
Cardiovascular RARE |
PH3 |
Apr 2026 slightly early |
62 |
51% |
Open |
| 160 |
Belite Bio, Inc. tinlarebant · Stargardt Disease (Ophthalmology)
Ophthalmology RARE |
PH3 |
Jun 2026 slightly early |
62 |
51% |
Open |
| 161 |
Ainos, Inc. Veldona · Sjogren's Disease
Autoimmune/immunology RARE |
PH3 |
Mar 2026 slightly early |
62 |
61% |
Open |
| 162 |
Ainos, Inc. Veldona · Sjogren's Disease
Autoimmune/immunology RARE |
PH3 |
Mar 2026 slightly early |
62 |
61% |
Open |
| 163 |
Roche Holding AG RG6179 · Uveitis (Ophthalmology)
Ophthalmology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
62 |
51% |
Amy |
| 164 |
Roche Holding AG RG6179 · Uveitis (Ophthalmology)
Ophthalmology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
62 |
51% |
Amy |
| 165 |
Roche Holding AG RG6179 · Uveitis (Ophthalmology)
Ophthalmology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
62 |
51% |
Amy |
| 166 |
ORCA Bio Inc. Orca-T · Hematologic Cancer
Oncology |
NDA/BLA |
Jun 2027 early — Tier 2 timing |
61 |
95% |
Dana |
| 167 |
Regeneron Pharmaceuticals, Inc. Ordspono · Diffuse Large B-Cell Lymphoma (DLBCL) - NHL
Oncology RARE |
PH3 |
Jul 2026 early — Tier 2 timing |
61 |
46% |
Dana |
| 168 |
Novartis AG Cosentyx · Lupus Nephritis
Autoimmune/immunology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
61 |
61% |
Dana |
| 169 |
Novartis AG Cosentyx · Lupus Nephritis
Autoimmune/immunology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
61 |
61% |
Dana |
| 170 |
Bristol Myers Squibb Company Arlo-cel · Multiple Myeloma (MM)
Oncology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
61 |
46% |
Steve |
| 171 |
Pfizer Inc. MET-097 · Obesity
Metabolic |
PH3 |
Apr 2026 slightly early |
61 |
64% |
Amy |
| 172 |
BridgeBio Pharma, Inc. Encaleret · Autosomal dominant hypocalcemia with hypercalciuria (ADHH)
Metabolic RARE |
PH3 |
Jun 2026 slightly early |
61 |
— |
Open |
| 173 |
AstraZeneca PLC Orpathys · Non-Small Cell Lung Cancer (NSCLC)
Oncology |
NDA/BLA |
Jul 2026 SWEET SPOT — ~12 mo to lau |
61 |
44% |
Dana |
| 174 |
United Therapeutics Corporation Ralinepag · Pulmonary Arterial Hypertension (PAH) and Pulmonary Hypertension (PH)
Cardiovascular RARE |
NDA/BLA |
Dec 2026 slightly early |
61 |
49% |
Steve |
| 175 |
Lyell Immunopharma Inc. Ronde-cel · Non-Hodgkin's Lymphoma (NHL)
Oncology |
PH3 |
Apr 2026 slightly early |
61 |
44% |
Open |
| 176 |
United Therapeutics Corporation Ralinepag · Pulmonary Arterial Hypertension (PAH) and Pulmonary Hypertension (PH)
Cardiovascular RARE |
PH3 |
Jun 2026 slightly early |
61 |
49% |
Steve |
| 177 |
Amgen, Inc. Bemarituzumab · Gastric Cancer
Oncology |
PH3 |
Jun 2026 slightly early |
61 |
44% |
Amy |
| 178 |
AstraZeneca PLC sonesitatug vedotin · Gastric Cancer
Oncology |
PH3 |
Jun 2026 slightly early |
61 |
44% |
Dana |
| 179 |
Shanghai Henlius Biotech , Inc. HLX22 · Gastric Cancer
Oncology |
PH3 |
Jun 2026 slightly early |
61 |
44% |
Open |
| 180 |
NewAmsterdam Pharma BV obicetrapib · Dyslipidemia / Hypercholesterolemia
Cardiovascular |
NDA/BLA |
Jun 2026 SWEET SPOT — ~12 mo to lau |
61 |
53% |
Steve |
| 181 |
Vertex Pharmaceuticals Incorporated zimislecel · Diabetes Mellitus, Type I
Endocrine |
NDA/BLA |
Dec 2026 slightly early |
61 |
63% |
Amy |
| 182 |
Roche Holding AG afimkibart · Ulcerative Colitis (UC)
Autoimmune/immunology |
PH3 |
Mar 2026 slightly early |
61 |
63% |
Amy |
| 183 |
Eli Lilly and Company Taltz · Obesity
Metabolic |
PH3 |
Jun 2026 slightly early |
61 |
63% |
Open |
| 184 |
Eli Lilly and Company Taltz · Obesity
Metabolic |
PH3 |
Jun 2026 slightly early |
61 |
63% |
Open |
| 185 |
Sanofi duvakitug · Ulcerative Colitis (UC)
Autoimmune/immunology |
PH3 |
Jun 2026 slightly early |
61 |
63% |
Amy |
| 186 |
Sanofi duvakitug · Ulcerative Colitis (UC)
Autoimmune/immunology |
PH3 |
Jun 2026 slightly early |
61 |
63% |
Amy |
| 187 |
Sanofi duvakitug · Crohn's Disease
Autoimmune/immunology |
PH3 |
Jun 2026 slightly early |
61 |
63% |
Amy |
| 188 |
Sanofi duvakitug · Crohn's Disease
Autoimmune/immunology |
PH3 |
Jun 2026 slightly early |
61 |
63% |
Amy |
| 189 |
MoonLake Immunotherapeutics AG sonelokimab · Psoriatic Arthritis (PsA)
Autoimmune/immunology |
PH3 |
Jun 2026 slightly early |
61 |
62% |
Open |
| 190 |
MoonLake Immunotherapeutics AG sonelokimab · Psoriatic Arthritis (PsA)
Autoimmune/immunology |
PH3 |
Jun 2026 slightly early |
61 |
62% |
Open |
| 191 |
Krystal Biotech, Inc. KB803 · Epidermolysis Bullosa
Metabolic RARE |
PH3 |
Jun 2026 slightly early |
61 |
58% |
Dana |
| 192 |
Roche Holding AG Tecentriq · Esophageal Cancer
Oncology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
61 |
44% |
Amy |
| 193 |
Stealth BioTherapeutics Inc. Forzinity · Primary Mitochondrial Myopathies (PMM)
Metabolic RARE |
PH3 |
Jul 2026 early — Tier 2 timing |
61 |
58% |
Open |
| 194 |
GSK plc Exdensur · Inflammatory Disorders
Autoimmune/immunology |
NDA/BLA |
Dec 2026 slightly early |
61 |
61% |
Dana |
| 195 |
Viking Therapeutics, Inc. VK2735 · Obesity
Metabolic |
PH3 |
Mar 2026 slightly early |
61 |
61% |
Dana |
| 196 |
Arrowhead Pharmaceuticals, Inc. Redemplo · Dyslipidemia / Hypercholesterolemia
Cardiovascular |
PH3 |
Mar 2026 slightly early |
61 |
51% |
Amy |
| 197 |
Immunovant, Inc. Batoclimab · Thyroid Eye Disease (TED)
Ophthalmology |
PH3 |
Jun 2026 slightly early |
61 |
51% |
Open |
| 198 |
Immunovant, Inc. Batoclimab · Thyroid Eye Disease (TED)
Ophthalmology |
PH3 |
Jun 2026 slightly early |
61 |
51% |
Open |
| 199 |
Oncolytics Biotech, Inc. pelareorep · Pancreatic Cancer
Oncology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
61 |
43% |
Open |
| 200 |
Polarity Bio SkinTE · Diabetic Foot and Other Ulcers
Endocrine |
PH3 |
Mar 2026 slightly early |
60 |
60% |
Open |
| 201 |
Zealand Pharma A/S Survodutide · Obesity
Metabolic |
PH3 |
Jun 2026 slightly early |
60 |
60% |
Dana |
| 202 |
Zealand Pharma A/S Survodutide · Obesity
Metabolic |
PH3 |
Jun 2026 slightly early |
60 |
60% |
Dana |
| 203 |
Palatin Technologies, Inc. PL9643 · Dry Eye (Ophthalmology)
Ophthalmology |
NDA/BLA |
Jun 2026 SWEET SPOT — ~12 mo to lau |
60 |
50% |
Open |
| 204 |
CEL-SCI Corporation Multikine · Head and Neck Cancer
Oncology |
PH3 |
Mar 2026 slightly early |
60 |
40% |
Amy |
| 205 |
BeOne Medicines Ltd. BGB-16673 · Chronic Lymphocytic Leukemia (CLL)/Small Cell Lymphocytic Lymphoma (SLL) - NHL
Oncology RARE |
PH3 |
Jun 2026 slightly early |
60 |
46% |
Steve |
| 206 |
BeOne Medicines Ltd. BGB-16673 · Chronic Lymphocytic Leukemia (CLL)/Small Cell Lymphocytic Lymphoma (SLL) - NHL
Oncology RARE |
PH3 |
Jun 2026 slightly early |
60 |
46% |
Steve |
| 207 |
CEL-SCI Corporation Multikine · Head and Neck Cancer
Oncology |
PH3 |
Jun 2026 slightly early |
60 |
40% |
Amy |
| 208 |
Lundbeck Lu AF82422 · Multiple System Atrophy (MSA)
Neurology RARE |
PH3 |
Sep 2026 early — Tier 2 timing |
60 |
46% |
Steve |
| 209 |
Ionis Pharmaceuticals, Inc. ION-581 · Angelman Syndrome
Neurology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
60 |
46% |
Amy |
| 210 |
Neurogene Inc. NGN-401 · Rett Syndrome
Neurology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
60 |
46% |
Open |
| 211 |
Neurogene Inc. NGN-401 · Rett Syndrome
Neurology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
60 |
46% |
Open |
| 212 |
Otsuka Holdings Co., Ltd. Ulefnersen · Amyotrophic Lateral Sclerosis (ALS)
Neurology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
60 |
46% |
Amy |
| 213 |
Roche Holding AG Enspryng · Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease (MOGAD)
Neurology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
60 |
46% |
Amy |
| 214 |
Roche Holding AG Enspryng · Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease (MOGAD)
Neurology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
60 |
46% |
Amy |
| 215 |
Roche Holding AG Enspryng · Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease (MOGAD)
Neurology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
60 |
46% |
Amy |
| 216 |
Roche Holding AG Lunsumio · Diffuse Large B-Cell Lymphoma (DLBCL) - NHL
Oncology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
60 |
50% |
Amy |
| 217 |
Roche Holding AG Lunsumio · Diffuse Large B-Cell Lymphoma (DLBCL) - NHL
Oncology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
60 |
50% |
Amy |
| 218 |
Roche Holding AG Lunsumio · Diffuse Large B-Cell Lymphoma (DLBCL) - NHL
Oncology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
60 |
50% |
Amy |
| 219 |
Alzheon Inc. ALZ-801 · Alzheimer's Disease (AD)
Neurology |
NDA/BLA |
Jul 2026 SWEET SPOT — ~12 mo to lau |
60 |
48% |
Dana |
| 220 |
Zealand Pharma A/S Survodutide · Diabetes Mellitus, Type II
Endocrine |
PH3 |
Jun 2026 slightly early |
60 |
58% |
Dana |
| 221 |
Exelixis, Inc. XL092 · Renal Cell Cancer (RCC)
Oncology RARE |
PH3 |
Jun 2026 slightly early |
60 |
44% |
Dana |
| 222 |
Diamyd Medical AB Diamyd · Diabetes Mellitus, Type I
Endocrine |
PH3 |
Mar 2026 slightly early |
60 |
47% |
Amy |
| 223 |
Novo Nordisk A/S CagriSema · Diabetes Mellitus, Type II
Endocrine |
PH3 |
Mar 2026 slightly early |
60 |
57% |
Open |
| 224 |
Amylyx Pharmaceuticals, Inc. avexitide acetate · Hyperinsulinemia/Hypoglycemia
Endocrine |
PH3 |
Jun 2026 slightly early |
60 |
57% |
Amy |
| 225 |
Zealand Pharma A/S Glepaglutide · Short Bowel Syndrome (SBS)
Gastroenterology (Non Inflammatory Bowel Disease) RARE |
PH3 |
Sep 2026 early — Tier 2 timing |
60 |
58% |
Dana |
| 226 |
ImmunityBio Inc. Anktiva · Non-Small Cell Lung Cancer (NSCLC)
Oncology |
NDA/BLA |
Jun 2027 early — Tier 2 timing |
60 |
99% |
Open |
| 227 |
Praxis Precision Medicines, Inc. PRAX-222 · Seizure Disorders (Epilepsy)
Neurology |
PH3 |
Jun 2026 slightly early |
60 |
46% |
Dana |
| 228 |
Arcus Biosciences, Inc. domvanalimab · Non-Small Cell Lung Cancer (NSCLC)
Oncology |
PH3 |
Jun 2026 slightly early |
60 |
46% |
Dana |
| 229 |
Arcus Biosciences, Inc. domvanalimab · Non-Small Cell Lung Cancer (NSCLC)
Oncology |
PH3 |
Jun 2026 slightly early |
60 |
46% |
Dana |
| 230 |
Arcus Biosciences, Inc. domvanalimab · Non-Small Cell Lung Cancer (NSCLC)
Oncology |
PH3 |
Jun 2026 slightly early |
60 |
46% |
Dana |
| 231 |
Johnson & Johnson Hensify · Head and Neck Cancer
Oncology |
PH3 |
Jun 2026 slightly early |
60 |
46% |
Steve |
| 232 |
Regeneron Pharmaceuticals, Inc. Libtayo · Melanoma
Oncology |
PH3 |
Jun 2026 slightly early |
60 |
46% |
Dana |
| 233 |
Regeneron Pharmaceuticals, Inc. REGN-3767 · Melanoma
Oncology |
PH3 |
Jun 2026 slightly early |
60 |
46% |
Dana |
| 234 |
AbbVie Inc. Sura-vec · Wet Age-Related Macular Degeneration (Wet AMD) (Ophthalmology)
Ophthalmology |
PH3 |
Jun 2026 slightly early |
59 |
55% |
Open |
| 235 |
AbbVie Inc. Sura-vec · Wet Age-Related Macular Degeneration (Wet AMD) (Ophthalmology)
Ophthalmology |
PH3 |
Jun 2026 slightly early |
59 |
55% |
Open |
| 236 |
Eli Lilly and Company Mounjaro · Chronic Heart Failure - Preserved Ejection Fraction (Chronic HFpEF)
Cardiovascular |
PH3 |
Jun 2026 slightly early |
59 |
55% |
Open |
| 237 |
Kodiak Sciences Inc. KSI-301 · Diabetic Retinopathy (Ophthalmology)
Ophthalmology |
PH3 |
Mar 2026 slightly early |
59 |
54% |
Amy |
| 238 |
BeOne Medicines Ltd. Tevimbra · Non-Small Cell Lung Cancer (NSCLC)
Oncology |
PH3 |
Mar 2026 slightly early |
59 |
44% |
Steve |
| 239 |
Mesoblast Limited Revascor · Chronic Heart Failure - Reduced Ejection Fraction (Chronic HFrEF)
Cardiovascular |
PH3 |
Mar 2026 slightly early |
59 |
44% |
Amy |
| 240 |
Immatics N.V. Anzu-cel · Melanoma
Oncology |
PH3 |
Apr 2026 slightly early |
59 |
44% |
Open |
| 241 |
Photocure ASA Cevira · Cervical Dysplasia
Oncology |
PH3 |
May 2026 slightly early |
59 |
44% |
Open |
| 242 |
AstraZeneca PLC rilvegostomig · Non-Small Cell Lung Cancer (NSCLC)
Oncology |
PH3 |
Jun 2026 slightly early |
59 |
44% |
Dana |
| 243 |
Immunocore, Ltd. Kimmtrak · Melanoma
Oncology |
PH3 |
Jun 2026 slightly early |
59 |
44% |
Amy |
| 244 |
Johnson & Johnson Rybrevant · Colorectal Cancer (CRC)
Oncology |
PH3 |
Jun 2026 slightly early |
59 |
44% |
Steve |
| 245 |
Roche Holding AG Tecentriq · Triple-Negative Breast Cancer (TNBC)
Oncology |
PH3 |
Jun 2026 slightly early |
59 |
44% |
Amy |
| 246 |
Incyte Corporation Monjuvi · Marginal Zone Lymphoma - NHL
Oncology RARE |
PH3 |
Jul 2026 early — Tier 2 timing |
59 |
45% |
Steve |
| 247 |
Bristol Myers Squibb Company RYZ101 · Neuroendocrine Tumors (NET)
Oncology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
59 |
44% |
Steve |
| 248 |
Takeda Pharmaceutical Co. Ltd. elritercept · Myelodysplastic Syndrome (MDS)
Oncology RARE |
PH3 |
Mar 2027 early — Tier 2 timing |
59 |
44% |
Dana |
| 249 |
Mesoblast Limited rexlemestrocel-L · Chronic Low Back Pain (CLBP)
Neurology |
PH3 |
Apr 2026 slightly early |
59 |
52% |
Amy |
| 250 |
Kodiak Sciences Inc. tabirafusp alfa · Diabetic Macular Edema (Ophthalmology)
Ophthalmology |
PH3 |
Feb 2026 slightly early |
59 |
51% |
Amy |
| 251 |
4D Molecular Therapeutics 4D-150 · Wet Age-Related Macular Degeneration (Wet AMD) (Ophthalmology)
Ophthalmology |
PH3 |
Mar 2026 slightly early |
59 |
51% |
Open |
| 252 |
4D Molecular Therapeutics 4D-150 · Wet Age-Related Macular Degeneration (Wet AMD) (Ophthalmology)
Ophthalmology |
PH3 |
Mar 2026 slightly early |
59 |
51% |
Open |
| 253 |
4D Molecular Therapeutics 4D-150 · Wet Age-Related Macular Degeneration (Wet AMD) (Ophthalmology)
Ophthalmology |
PH3 |
Mar 2026 slightly early |
59 |
51% |
Open |
| 254 |
4D Molecular Therapeutics 4D-150 · Wet Age-Related Macular Degeneration (Wet AMD) (Ophthalmology)
Ophthalmology |
PH3 |
Mar 2026 slightly early |
59 |
51% |
Open |
| 255 |
Novartis AG Beovu · Diabetic Retinopathy (Ophthalmology)
Ophthalmology |
PH3 |
Mar 2026 slightly early |
59 |
51% |
Dana |
| 256 |
Roche Holding AG Enspryng · Thyroid Eye Disease (TED)
Ophthalmology |
PH3 |
Jun 2026 slightly early |
59 |
51% |
Amy |
| 257 |
Viridian Therapeutics, Inc. elegrobart · Other Ophthalmological Indications (Ophthalmology)
Ophthalmology |
PH3 |
Jun 2026 slightly early |
59 |
51% |
Steve |
| 258 |
Viridian Therapeutics, Inc. elegrobart · Other Ophthalmological Indications (Ophthalmology)
Ophthalmology |
PH3 |
Jun 2026 slightly early |
59 |
51% |
Steve |
| 259 |
Dianthus Therapeutics claseprubart · Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Neurology RARE |
PH3 |
Jul 2026 early — Tier 2 timing |
58 |
46% |
Open |
| 260 |
argenx N.V. empasiprubart · Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Neurology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
58 |
46% |
Steve |
| 261 |
Roche Holding AG RG6299 · Immunoglobulin A (IgA) Nephropathy (Berger's Disease)
Renal RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
58 |
46% |
Amy |
| 262 |
Outlook Therapeutics, Inc. Lytenava · Wet Age-Related Macular Degeneration (Wet AMD) (Ophthalmology)
Ophthalmology |
PH3 |
Mar 2026 slightly early |
58 |
49% |
Steve |
| 263 |
Outlook Therapeutics, Inc. Lytenava · Wet Age-Related Macular Degeneration (Wet AMD) (Ophthalmology)
Ophthalmology |
PH3 |
Apr 2026 slightly early |
58 |
49% |
Steve |
| 264 |
Roche Holding AG Pegozafermin · Dyslipidemia / Hypercholesterolemia
Cardiovascular |
PH3 |
Mar 2026 slightly early |
58 |
48% |
Amy |
| 265 |
Novartis AG pelacarsen · Dyslipidemia / Hypercholesterolemia
Cardiovascular |
NDA/BLA |
Dec 2026 slightly early |
58 |
47% |
Dana |
| 266 |
Meilleur Technologies, Inc. NAV4694 · Alzheimer's Disease - Imaging
Neurology |
NDA/BLA |
Dec 2026 slightly early |
58 |
46% |
Open |
| 267 |
Renibus Therapeutics Inc. RBT-1 · Cardiac Valve Surgery
Cardiovascular |
PH3 |
Apr 2026 slightly early |
58 |
46% |
Steve |
| 268 |
Renibus Therapeutics Inc. RBT-1 · Coronary Artery Bypass Graft (CABG)
Cardiovascular |
PH3 |
Apr 2026 slightly early |
58 |
46% |
Steve |
| 269 |
BrainStorm Cell Therapeutics Inc. NurOwn · Amyotrophic Lateral Sclerosis (ALS)
Neurology RARE |
PH3 |
Mar 2027 early — Tier 2 timing |
57 |
32% |
Amy |
| 270 |
Theravance Biopharma Inc. TD-9855 · Orthostatic Hypotension
Cardiovascular RARE |
PH3 |
Mar 2026 slightly early |
57 |
28% |
Open |
| 271 |
Forma Therapeutics Inc. etavopivat · Sickle Cell Disease
Hematology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
56 |
75% |
Open |
| 272 |
Nippon Shinyaku Co., Ltd. Deramiocel · Duchenne Muscular Dystrophy (DMD)
Metabolic RARE |
PH3 |
May 2027 too early — 30+ mo out |
56 |
70% |
Open |
| 273 |
Vivet Therapeutics VTX-801 · Wilson's Disease
Metabolic RARE |
NDA/BLA |
Jun 2027 early — Tier 2 timing |
56 |
25% |
Open |
| 274 |
Disc Medicine, Inc. DISC-1459 · Porphyria
Metabolic RARE |
PDUFA |
Jun 2026 launching <6 mo — conversa |
55 |
92% |
Open |
| 275 |
Sarepta Therapeutics, Inc. SRP-9003 · Limb-Girdle Muscular Dystrophy (LGMD)
Metabolic RARE |
PH3 |
May 2027 too early — 30+ mo out |
55 |
62% |
Steve |
| 276 |
Intellia Therapeutics, Inc. Nex-z · Hereditary Transthyretin (hATTR) Amyloidosis With Polyneuropathy (Familial Amyloid Polyneuropathy)
Metabolic RARE |
NDA/BLA |
Dec 2028 too early — 30+ mo out |
54 |
61% |
Open |
| 277 |
Intellia Therapeutics, Inc. Nex-z · Hereditary Transthyretin (hATTR) Amyloidosis With Polyneuropathy (Familial Amyloid Polyneuropathy)
Metabolic RARE |
PH3 |
Jun 2027 too early — 30+ mo out |
54 |
61% |
Open |
| 278 |
Intellia Therapeutics, Inc. lonvoguran ziclumeran · Hereditary Angioedema (HAE)
Autoimmune/immunology RARE |
PH3 |
Jun 2027 too early — 30+ mo out |
54 |
61% |
Open |
| 279 |
Novartis AG ianalumab · Immune Thrombocytopenic Purpura (ITP)
Autoimmune/immunology RARE |
PH3 |
Jul 2027 too early — 30+ mo out |
54 |
61% |
Dana |
| 280 |
Intellia Therapeutics, Inc. Nex-z · Hereditary Transthyretin (hATTR) Amyloidosis With Polyneuropathy (Familial Amyloid Polyneuropathy)
Metabolic RARE |
PH3 |
Dec 2028 too early — 30+ mo out |
54 |
61% |
Open |
| 281 |
Takeda Pharmaceutical Co. Ltd. mezagitamab · Immune Thrombocytopenic Purpura (ITP)
Autoimmune/immunology RARE |
PH3 |
Dec 2028 too early — 30+ mo out |
54 |
61% |
Dana |
| 282 |
Ocugen Inc. OCU400 · Retinitis Pigmentosa (RP) (Ophthalmology)
Ophthalmology RARE |
PH3 |
Dec 2027 too early — 30+ mo out |
54 |
— |
Steve |
| 283 |
Ocugen Inc. OCU400 · Retinitis Pigmentosa (RP) (Ophthalmology)
Ophthalmology RARE |
PH3 |
Dec 2027 too early — 30+ mo out |
54 |
— |
Steve |
| 284 |
Agenus Inc. Botensilimab · Colorectal Cancer (CRC)
Oncology |
NDA/BLA |
Jul 2026 SWEET SPOT — ~12 mo to lau |
54 |
12% |
Dana |
| 285 |
Intellia Therapeutics, Inc. Nex-z · Transthyretin Amyloid Cardiomyopathy (ATTR-CM, Wild Type Or Hereditary)
Metabolic RARE |
PH3 |
Jun 2027 too early — 30+ mo out |
54 |
59% |
Open |
| 286 |
Intellia Therapeutics, Inc. Nex-z · Transthyretin Amyloid Cardiomyopathy (ATTR-CM, Wild Type Or Hereditary)
Metabolic RARE |
PH3 |
Jun 2027 too early — 30+ mo out |
54 |
59% |
Open |
| 287 |
Roche Holding AG Piasky · Hemolytic Uremic Syndrome (HUS)
Hematology RARE |
PH3 |
Jun 2027 too early — 30+ mo out |
54 |
71% |
Amy |
| 288 |
JCR Pharmaceuticals Co., Ltd. JR-141 · Mucopolysaccharidosis II (MPS II; Hunter Syndrome)
Metabolic RARE |
NDA/BLA |
Mar 2028 too early — 30+ mo out |
54 |
58% |
Open |
| 289 |
Lantheus Holdings, Inc. Neuraceq · Transthyretin Amyloid Cardiomyopathy (ATTR-CM, Wild Type Or Hereditary)
Metabolic RARE |
PH3 |
Apr 2027 too early — 30+ mo out |
54 |
58% |
Dana |
| 290 |
JCR Pharmaceuticals Co., Ltd. JR-141 · Mucopolysaccharidosis II (MPS II; Hunter Syndrome)
Metabolic RARE |
PH3 |
May 2027 too early — 30+ mo out |
54 |
58% |
Open |
| 291 |
Avidity Biosciences, Inc. Del-desiran · Myotonic Muscular Dystrophy
Metabolic RARE |
PH3 |
Jun 2027 too early — 30+ mo out |
54 |
58% |
Steve |
| 292 |
Rafael Holdings, Inc. Trappsol Cyclo · Niemann-Pick Disease Type C
Metabolic RARE |
PH3 |
Jun 2027 too early — 30+ mo out |
54 |
58% |
Open |
| 293 |
Rafael Holdings, Inc. Trappsol Cyclo · Niemann-Pick Disease Type C
Metabolic RARE |
PH3 |
Jun 2027 too early — 30+ mo out |
54 |
58% |
Open |
| 294 |
Avidity Biosciences, Inc. Del-desiran · Myotonic Muscular Dystrophy
Metabolic RARE |
PH3 |
Jul 2027 too early — 30+ mo out |
54 |
58% |
Steve |
| 295 |
JCR Pharmaceuticals Co., Ltd. JR-141 · Mucopolysaccharidosis II (MPS II; Hunter Syndrome)
Metabolic RARE |
PH3 |
Mar 2028 too early — 30+ mo out |
54 |
58% |
Open |
| 296 |
Ocugen Inc. OCU400 · Leber's Congenital Amaurosis (Ophthalmology)
Ophthalmology RARE |
NDA/BLA |
Jun 2027 early — Tier 2 timing |
54 |
24% |
Steve |
| 297 |
AstraZeneca PLC GC012F · Multiple Myeloma (MM)
Oncology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
54 |
11% |
Dana |
| 298 |
AstraZeneca PLC GC012F · Multiple Myeloma (MM)
Oncology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
54 |
11% |
Dana |
| 299 |
AstraZeneca PLC GC012F · Multiple Myeloma (MM)
Oncology RARE |
PH3 |
Mar 2027 early — Tier 2 timing |
54 |
11% |
Dana |
| 300 |
Neurizon Therapeutics NUZ-001 · Amyotrophic Lateral Sclerosis (ALS)
Neurology RARE |
NDA/BLA |
Jun 2027 early — Tier 2 timing |
54 |
— |
Open |
| 301 |
Ellodi Pharmaceuticals APT-1011 · Eosinophilic Esophagitis (EoE)
Autoimmune/immunology RARE |
PH3 |
Jul 2026 early — Tier 2 timing |
54 |
— |
Open |
| 302 |
Immedica Pharma AB Loargys · Urea Cycle Disorders and Derangements (UCD)
Metabolic |
PDUFA |
Nov 2026 launching <6 mo — conversa |
54 |
88% |
Dana |
| 303 |
Ascentage Pharma Group Corporation Lisento · Myelodysplastic Syndrome (MDS)
Oncology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
54 |
48% |
Open |
| 304 |
Ascentage Pharma Group Corporation Lisento · Myelodysplastic Syndrome (MDS)
Oncology RARE |
PH3 |
Feb 2027 early — Tier 2 timing |
54 |
48% |
Open |
| 305 |
Organogenesis Inc. ReNu · Osteoarthritis
Rheumatology (Non Autoimmune) |
PH3 |
Jun 2026 slightly early |
53 |
40% |
Open |
| 306 |
Otsuka America Inc. JNT-517 · Phenylketonuria (PKU)
Metabolic RARE |
PH3 |
Jul 2026 early — Tier 2 timing |
53 |
58% |
Amy |
| 307 |
Novartis AG Pelabresib · Myelofibrosis (MF)
Oncology RARE |
PH3 |
Jul 2026 early — Tier 2 timing |
53 |
47% |
Dana |
| 308 |
Novartis AG Pelabresib · Myelofibrosis (MF)
Oncology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
53 |
47% |
Dana |
| 309 |
Otsuka America Inc. JNT-517 · Phenylketonuria (PKU)
Metabolic RARE |
PH3 |
Mar 2027 early — Tier 2 timing |
53 |
58% |
Amy |
| 310 |
Johnson & Johnson Bota-vec · Retinitis Pigmentosa (RP) (Ophthalmology)
Ophthalmology RARE |
PH3 |
Jun 2027 too early — 30+ mo out |
53 |
54% |
Steve |
| 311 |
Lumos Pharma, Inc. Oratrope · Short Stature / Growth Hormone Deficiency
Endocrine RARE |
PH3 |
Jul 2026 early — Tier 2 timing |
53 |
57% |
Open |
| 312 |
BridgeBio Pharma, Inc. Encaleret · Hypoparathyroidism
Endocrine RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
53 |
57% |
Open |
| 313 |
BridgeBio Pharma, Inc. Encaleret · Hypoparathyroidism
Endocrine RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
53 |
57% |
Open |
| 314 |
MAIA Biotechnology, Inc. THIO · Non-Small Cell Lung Cancer (NSCLC)
Oncology |
NDA/BLA |
Dec 2026 slightly early |
53 |
15% |
Open |
| 315 |
Roche Holding AG RG6179 · Diabetic Macular Edema (Ophthalmology)
Ophthalmology |
NDA/BLA |
Dec 2026 slightly early |
53 |
24% |
Amy |
| 316 |
GenSight Biologics S.A. Lumevoq · Leber's Hereditary Optic Neuropathy (LHON) (Ophthalmology)
Ophthalmology RARE |
PH3 |
May 2027 too early — 30+ mo out |
53 |
53% |
Open |
| 317 |
GenSight Biologics S.A. Lumevoq · Leber's Hereditary Optic Neuropathy (LHON) (Ophthalmology)
Ophthalmology RARE |
PH3 |
Jul 2027 too early — 30+ mo out |
53 |
53% |
Open |
| 318 |
GenSight Biologics S.A. Lumevoq · Leber's Hereditary Optic Neuropathy (LHON) (Ophthalmology)
Ophthalmology RARE |
PH3 |
Aug 2027 too early — 30+ mo out |
53 |
53% |
Open |
| 319 |
Cogent Biosciences, Inc. bezuclastinib · Gastrointestinal Stromal Tumor (GIST)
Oncology RARE |
PH3 |
Sep 2026 early — Tier 2 timing |
53 |
45% |
Dana |
| 320 |
Zentalis Pharmaceuticals azenosertib · Ovarian Cancer
Oncology RARE |
NDA/BLA |
Dec 2026 slightly early |
53 |
11% |
Open |
| 321 |
Eli Lilly and Company orforglipron · Diabetes Mellitus, Type II
Endocrine |
PH3 |
Mar 2026 slightly early |
53 |
72% |
Open |
| 322 |
Priothera Limited Mocravimod · Acute Myelogenous Leukemia (AML)
Oncology RARE |
PH3 |
Jul 2026 early — Tier 2 timing |
53 |
44% |
Open |
| 323 |
TMRC Co., Ltd. Amnolake · Myelodysplastic Syndrome (MDS)
Oncology RARE |
PH3 |
Jul 2026 early — Tier 2 timing |
53 |
44% |
Open |
| 324 |
Ascentage Pharma Group Corporation olverembatinib · Chronic Myelogenous Leukemia (CML)
Oncology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
53 |
44% |
Open |
| 325 |
Ascentage Pharma Group Corporation olverembatinib · Acute Lymphoblastic Leukemia (ALL)
Oncology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
53 |
44% |
Open |
| 326 |
Karyopharm Therapeutics Xpovio · Myelofibrosis (MF)
Oncology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
53 |
44% |
Steve |
| 327 |
Revolution Medicines, Inc. RMC-6236 · Pancreatic Cancer
Oncology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
53 |
44% |
Open |
| 328 |
EUSA Pharma (UK) Ltd. Qarziba · Neuroblastoma
Oncology RARE |
NDA/BLA |
Jul 2027 early — Tier 2 timing |
53 |
6% |
Open |
| 329 |
Arrowhead Pharmaceuticals, Inc. zodasiran · Homozygous Familial Hypercholesterolemia (HoFH)
Cardiovascular RARE |
PH3 |
May 2027 too early — 30+ mo out |
53 |
51% |
Amy |
| 330 |
Arrowhead Pharmaceuticals, Inc. zodasiran · Homozygous Familial Hypercholesterolemia (HoFH)
Cardiovascular RARE |
PH3 |
Jun 2027 too early — 30+ mo out |
53 |
51% |
Amy |
| 331 |
Apnimed atomoxetine · Sleep Apnea
Respiratory |
NDA/BLA |
Apr 2026 SWEET SPOT — ~12 mo to lau |
52 |
62% |
Open |
| 332 |
BioMarin Pharmaceutical Inc. INZ-701 · Metabolic - General
Metabolic |
PH3 |
Jul 2026 early — Tier 2 timing |
52 |
58% |
Amy |
| 333 |
BioMarin Pharmaceutical Inc. INZ-701 · Metabolic - General
Metabolic |
PH3 |
Jul 2026 early — Tier 2 timing |
52 |
58% |
Amy |
| 334 |
BioMarin Pharmaceutical Inc. INZ-701 · Metabolic - General
Metabolic |
PH3 |
Oct 2026 early — Tier 2 timing |
52 |
58% |
Amy |
| 335 |
Novartis AG Cosentyx · Giant Cell Arteritis
Autoimmune/immunology RARE |
PH3 |
Jun 2027 too early — 30+ mo out |
52 |
61% |
Dana |
| 336 |
Novartis AG Cosentyx · Giant Cell Arteritis
Autoimmune/immunology RARE |
PH3 |
Jun 2027 too early — 30+ mo out |
52 |
61% |
Dana |
| 337 |
Praxis Precision Medicines, Inc. relutrigine · Seizure Disorders (Epilepsy)
Neurology |
NDA/BLA |
Feb 2026 approaching sweet spot |
52 |
46% |
Dana |
| 338 |
Idorsia Pharmaceuticals Ltd lucerastat · Fabry's Disease
Metabolic RARE |
PH3 |
Mar 2027 early — Tier 2 timing |
52 |
52% |
Dana |
| 339 |
Lexicon Pharmaceuticals, Inc. Inpefa · Diabetes Mellitus, Type I
Endocrine |
PDUFA |
Dec 2026 approaching sweet spot |
52 |
57% |
Steve |
| 340 |
Novartis AG NeoBOMB1 · Solid Tumors
Oncology |
NDA/BLA |
Dec 2026 slightly early |
52 |
11% |
Dana |
| 341 |
Theralase Technologies Inc. Ruvidar · Bladder Cancer
Oncology |
NDA/BLA |
Dec 2026 slightly early |
52 |
11% |
Open |
| 342 |
Immunovant, Inc. imeroprubart · Myasthenia Gravis (MG)
Autoimmune/immunology RARE |
NDA/BLA |
Dec 2028 too early — 30+ mo out |
52 |
— |
Open |
| 343 |
Sun Pharmaceutical Industries Ltd. Winlevi / Breezula · Androgenetic Alopecia
Dermatology |
PH3 |
Jun 2026 slightly early |
52 |
68% |
Amy |
| 344 |
Sun Pharmaceutical Industries Ltd. Winlevi / Breezula · Androgenetic Alopecia
Dermatology |
PH3 |
Jun 2026 slightly early |
52 |
68% |
Amy |
| 345 |
AstraZeneca PLC volrustomig · Non-Small Cell Lung Cancer (NSCLC)
Oncology |
PH3 |
Jun 2026 slightly early |
52 |
11% |
Dana |
| 346 |
Immunovant, Inc. imeroprubart · Myasthenia Gravis (MG)
Autoimmune/immunology RARE |
PH3 |
Dec 2028 too early — 30+ mo out |
52 |
— |
Open |
| 347 |
Kubota Pharmaceutical Holdings Co., Ltd. ACU-4429 · Stargardt Disease (Ophthalmology)
Ophthalmology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
52 |
51% |
Open |
| 348 |
Amgen, Inc. Bemarituzumab · Gastric Cancer
Oncology |
NDA/BLA |
Jun 2027 early — Tier 2 timing |
52 |
44% |
Amy |
| 349 |
Faron Pharmaceuticals Oy FP-1305 · Myelodysplastic Syndrome (MDS)
Oncology RARE |
NDA/BLA |
Jun 2027 early — Tier 2 timing |
52 |
11% |
Open |
| 350 |
BioNTech SE gotistobart · Non-Small Cell Lung Cancer (NSCLC)
Oncology |
PH3 |
Dec 2026 early — Tier 2 timing |
52 |
44% |
Dana |
| 351 |
Shanghai Henlius Biotech , Inc. HLX22 · Gastric Cancer
Oncology |
PH3 |
Jan 2027 early — Tier 2 timing |
52 |
44% |
Open |
| 352 |
Lyell Immunopharma Inc. Ronde-cel · Non-Hodgkin's Lymphoma (NHL)
Oncology |
PH3 |
Mar 2027 early — Tier 2 timing |
52 |
44% |
Open |
| 353 |
Mirum Pharmaceuticals, Inc. brelovitug · Hepatitis D (HDV) (Antiviral)
Infectious Disease RARE |
PH3 |
Aug 2027 too early — 30+ mo out |
52 |
64% |
Steve |
| 354 |
Nuvalent, Inc. NVL-655 · Non-Small Cell Lung Cancer (NSCLC)
Oncology |
PH3 |
Jun 2026 slightly early |
52 |
54% |
Open |
| 355 |
Ionis Pharmaceuticals, Inc. ION-581 · Angelman Syndrome
Neurology RARE |
PH3 |
Dec 2027 too early — 30+ mo out |
52 |
46% |
Amy |
| 356 |
Sanofi SAR445088 · Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Neurology RARE |
PH3 |
Dec 2027 too early — 30+ mo out |
52 |
46% |
Amy |
| 357 |
Bristol Myers Squibb Company Sotyktu · Systemic Lupus Erythematosus (SLE)
Autoimmune/immunology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
52 |
61% |
Steve |
| 358 |
United Therapeutics Corporation Ralinepag · Pulmonary Arterial Hypertension (PAH) and Pulmonary Hypertension (PH)
Cardiovascular RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
52 |
49% |
Steve |
| 359 |
United Therapeutics Corporation Ralinepag · Pulmonary Arterial Hypertension (PAH) and Pulmonary Hypertension (PH)
Cardiovascular RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
52 |
49% |
Steve |
| 360 |
Ascendis Pharma A/S Skytrofa · Turner Syndrome
Endocrine RARE |
PH3 |
Jun 2027 too early — 30+ mo out |
52 |
57% |
Dana |
| 361 |
Gilead Sciences, Inc. Trodelvy · Non-Small Cell Lung Cancer (NSCLC)
Oncology |
PH3 |
Dec 2026 early — Tier 2 timing |
51 |
41% |
Amy |
| 362 |
Kyntra Bio, Inc. Evrenzo · Cancer-Related Anemia
Hematology |
PH3 |
Mar 2026 slightly early |
51 |
63% |
Open |
| 363 |
Mithra Pharmaceuticals SA Donesta · Menopause (including Hormone Replacement Therapy [HRT])
Endocrine |
PH3 |
Apr 2026 slightly early |
51 |
63% |
Open |
| 364 |
Pfizer Inc. MET-097 · Obesity
Metabolic |
PH3 |
Dec 2026 early — Tier 2 timing |
51 |
64% |
Amy |
| 365 |
Can-Fite BioPharma Ltd. Piclidenoson · Psoriasis
Autoimmune/immunology |
PH3 |
Dec 2026 early — Tier 2 timing |
51 |
63% |
Amy |
| 366 |
Vertex Pharmaceuticals Incorporated zimislecel · Diabetes Mellitus, Type I
Endocrine |
PH3 |
Dec 2026 early — Tier 2 timing |
51 |
63% |
Amy |
| 367 |
CEL-SCI Corporation Multikine · Head and Neck Cancer
Oncology |
PH3 |
Dec 2026 early — Tier 2 timing |
51 |
40% |
Amy |
| 368 |
AB Science S.A. Masican · Amyotrophic Lateral Sclerosis (ALS)
Neurology RARE |
PH3 |
Mar 2027 early — Tier 2 timing |
51 |
46% |
Open |
| 369 |
CEL-SCI Corporation Multikine · Head and Neck Cancer
Oncology |
PH3 |
Mar 2027 early — Tier 2 timing |
51 |
40% |
Amy |
| 370 |
UCB S.A. UCB0107 · Alzheimer's Disease (AD)
Neurology |
NDA/BLA |
Dec 2026 slightly early |
51 |
14% |
Amy |
| 371 |
Pfizer Inc. disitamab vedotin · Bladder Cancer
Oncology |
PH3 |
Dec 2026 early — Tier 2 timing |
51 |
50% |
Amy |
| 372 |
Bristol Myers Squibb Company BMS-986278 · Idiopathic Pulmonary Fibrosis (IPF)
Respiratory RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
51 |
62% |
Steve |
| 373 |
Bristol Myers Squibb Company Mezigdomide · Multiple Myeloma (MM)
Oncology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
51 |
45% |
Steve |
| 374 |
Bristol Myers Squibb Company Mezigdomide · Multiple Myeloma (MM)
Oncology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
51 |
45% |
Steve |
| 375 |
Arcus Biosciences, Inc. casdatifan · Renal Cell Cancer (RCC)
Oncology RARE |
PH3 |
Mar 2027 early — Tier 2 timing |
51 |
45% |
Dana |
| 376 |
Bristol Myers Squibb Company Mezigdomide · Multiple Myeloma (MM)
Oncology RARE |
PH3 |
Mar 2027 early — Tier 2 timing |
51 |
45% |
Steve |
| 377 |
Karyopharm Therapeutics Xpovio · Uterine (Endometrial) Cancer
Oncology RARE |
PH3 |
Mar 2027 early — Tier 2 timing |
51 |
45% |
Steve |
| 378 |
Zealand Pharma A/S Glepaglutide · Short Bowel Syndrome (SBS)
Gastroenterology (Non Inflammatory Bowel Disease) RARE |
PH3 |
Jun 2027 too early — 30+ mo out |
51 |
58% |
Dana |
| 379 |
Zealand Pharma A/S Glepaglutide · Short Bowel Syndrome (SBS)
Gastroenterology (Non Inflammatory Bowel Disease) RARE |
PH3 |
Jun 2027 too early — 30+ mo out |
51 |
58% |
Dana |
| 380 |
Bayer AG Kerendia · Chronic Kidney Disease (CKD)
Renal |
PH3 |
Mar 2026 slightly early |
51 |
— |
Amy |
| 381 |
Mineralys Therapeutics, Inc. Lorundrostat · Hypertension (Systemic)
Cardiovascular |
PH3 |
Mar 2026 slightly early |
51 |
60% |
Open |
| 382 |
Veru Inc. Ostarine · Obesity
Metabolic |
PH3 |
Mar 2026 slightly early |
51 |
60% |
Open |
| 383 |
GSK plc BOS-580 · Non-Alcoholic Steatohepatitis (NASH)
Endocrine |
PH3 |
Jul 2026 early — Tier 2 timing |
51 |
61% |
Dana |
| 384 |
GSK plc Exdensur · Inflammatory Disorders
Autoimmune/immunology |
PH3 |
Dec 2026 early — Tier 2 timing |
51 |
61% |
Dana |
| 385 |
GSK plc Exdensur · Inflammatory Disorders
Autoimmune/immunology |
PH3 |
Dec 2026 early — Tier 2 timing |
51 |
61% |
Dana |
| 386 |
GSK plc Exdensur · Inflammatory Disorders
Autoimmune/immunology |
PH3 |
Dec 2026 early — Tier 2 timing |
51 |
61% |
Dana |
| 387 |
GSK plc Exdensur · Inflammatory Disorders
Autoimmune/immunology |
PH3 |
Dec 2026 early — Tier 2 timing |
51 |
61% |
Dana |
| 388 |
Novartis AG Cosentyx · Inflammatory Disorders
Autoimmune/immunology |
PH3 |
Dec 2026 early — Tier 2 timing |
51 |
61% |
Dana |
| 389 |
Arcus Biosciences, Inc. domvanalimab · Gastric Cancer
Oncology |
PH3 |
Dec 2026 early — Tier 2 timing |
51 |
49% |
Dana |
| 390 |
Arcus Biosciences, Inc. Zimberelimab · Gastric Cancer
Oncology |
PH3 |
Dec 2026 early — Tier 2 timing |
51 |
49% |
Dana |
| 391 |
Polarity Bio SkinTE · Diabetic Foot and Other Ulcers
Endocrine |
PH3 |
Sep 2026 early — Tier 2 timing |
51 |
60% |
Open |
| 392 |
Zealand Pharma A/S Survodutide · Obesity
Metabolic |
PH3 |
Dec 2026 early — Tier 2 timing |
51 |
60% |
Dana |
| 393 |
Zealand Pharma A/S Survodutide · Obesity
Metabolic |
PH3 |
Dec 2026 early — Tier 2 timing |
51 |
60% |
Dana |
| 394 |
BeOne Medicines Ltd. sonrotoclax · Chronic Lymphocytic Leukemia (CLL)/Small Cell Lymphocytic Lymphoma (SLL) - NHL
Oncology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
51 |
44% |
Steve |
| 395 |
Bristol Myers Squibb Company Golcadomide · Follicular Lymphoma (FL)
Oncology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
51 |
44% |
Steve |
| 396 |
Incyte Corporation INCB123667 · Ovarian Cancer
Oncology RARE |
PH3 |
Dec 2026 early — Tier 2 timing |
51 |
44% |
Steve |
| 397 |
Kailera Therapeutics ribupatide · Obesity
Metabolic |
PH3 |
Mar 2027 early — Tier 2 timing |
51 |
— |
Open |
| 398 |
Praxis Precision Medicines, Inc. relutrigine · Seizure Disorders (Epilepsy)
Neurology |
PH3 |
Feb 2026 slightly early |
50 |
46% |
Dana |
| 399 |
Ionis Pharmaceuticals, Inc. Tryngolza · Dyslipidemia / Hypercholesterolemia
Cardiovascular |
PH3 |
Dec 2026 early — Tier 2 timing |
50 |
59% |
Amy |
| 400 |
Reviva Pharmaceuticals Holdings, Inc. brilaroxazine · Schizophrenia
Psychiatry |
PH3 |
Jun 2026 slightly early |
50 |
58% |
Open |
| 401 |
Olema Pharmaceuticals, Inc. palazestrant · HR+/HER2- Breast Cancer
Oncology |
PH3 |
Jun 2026 slightly early |
50 |
46% |
Open |
| 402 |
Daiichi Sankyo Co., Ltd. Enhertu · Ovarian Cancer
Oncology RARE |
PH3 |
Jun 2027 too early — 30+ mo out |
50 |
44% |
Dana |
| 403 |
Merck & Co., Inc. Jiatailai · Ovarian Cancer
Oncology RARE |
PH3 |
Jul 2027 too early — 30+ mo out |
50 |
44% |
Open |
| 404 |
Merck & Co., Inc. Jiatailai · Cervical Cancer
Oncology RARE |
PH3 |
Aug 2027 too early — 30+ mo out |
50 |
44% |
Open |
| 405 |
Merck & Co., Inc. Jiatailai · Ovarian Cancer
Oncology RARE |
PH3 |
Aug 2027 too early — 30+ mo out |
50 |
44% |
Open |
| 406 |
Clene, Inc. CNM-Au8 · Amyotrophic Lateral Sclerosis (ALS)
Neurology RARE |
NDA/BLA |
Jun 2027 early — Tier 2 timing |
50 |
41% |
Open |
| 407 |
Regeneron Pharmaceuticals, Inc. REGN-3767 · Melanoma
Oncology |
NDA/BLA |
Jun 2027 early — Tier 2 timing |
50 |
46% |
Dana |
| 408 |
Merck & Co., Inc. enlicitide decanoate · Dyslipidemia / Hypercholesterolemia
Cardiovascular |
PH3 |
Apr 2026 slightly early |
50 |
57% |
Open |
| 409 |
AstraZeneca PLC Tozorakimab · Chronic Obstructive Pulmonary Disease (COPD)
Respiratory |
PH3 |
Jun 2026 slightly early |
50 |
62% |
Dana |
| 410 |
AstraZeneca PLC Tozorakimab · Chronic Obstructive Pulmonary Disease (COPD)
Respiratory |
PH3 |
Jun 2026 slightly early |
50 |
62% |
Dana |
| 411 |
AstraZeneca PLC Tozorakimab · Chronic Obstructive Pulmonary Disease (COPD)
Respiratory |
PH3 |
Jun 2026 slightly early |
50 |
62% |
Dana |
| 412 |
Regeneron Pharmaceuticals, Inc. Itepekimab · Chronic Obstructive Pulmonary Disease (COPD)
Respiratory |
PH3 |
Jun 2026 slightly early |
50 |
62% |
Dana |
| 413 |
Regeneron Pharmaceuticals, Inc. Itepekimab · Chronic Obstructive Pulmonary Disease (COPD)
Respiratory |
PH3 |
Jun 2026 slightly early |
50 |
62% |
Dana |
| 414 |
Johnson & Johnson Hensify · Head and Neck Cancer
Oncology |
PH3 |
Jul 2026 early — Tier 2 timing |
50 |
46% |
Steve |
| 415 |
Merck & Co., Inc. Jiatailai · Non-Small Cell Lung Cancer (NSCLC)
Oncology |
PH3 |
Oct 2026 early — Tier 2 timing |
50 |
46% |
Open |
| 416 |
Arcus Biosciences, Inc. domvanalimab · Non-Small Cell Lung Cancer (NSCLC)
Oncology |
PH3 |
Oct 2026 early — Tier 2 timing |
50 |
46% |
Dana |
| 417 |
Arcus Biosciences, Inc. Zimberelimab · Non-Small Cell Lung Cancer (NSCLC)
Oncology |
PH3 |
Oct 2026 early — Tier 2 timing |
50 |
46% |
Dana |
| 418 |
Curium Pharma Lu-177-PSMA-I&T · Prostate Cancer
Oncology |
PH3 |
Dec 2026 early — Tier 2 timing |
50 |
46% |
Dana |
| 419 |
Praxis Precision Medicines, Inc. PRAX-222 · Seizure Disorders (Epilepsy)
Neurology |
PH3 |
Dec 2026 early — Tier 2 timing |
50 |
46% |
Dana |
| 420 |
Rakuten Medical, Inc. ASP-1929 · Head and Neck Cancer
Oncology |
PH3 |
Dec 2026 early — Tier 2 timing |
50 |
46% |
Open |
| 421 |
Praxis Precision Medicines, Inc. PRAX-222 · Seizure Disorders (Epilepsy)
Neurology |
PH3 |
Mar 2027 early — Tier 2 timing |
50 |
46% |
Dana |
| 422 |
Definium Therapeutics, Inc. MM-120 · Generalized Anxiety Disorder (GAD)
Psychiatry |
PH3 |
Jun 2026 slightly early |
50 |
56% |
Open |
| 423 |
Helixmith Co., Ltd. Engensis · Diabetic Foot and Other Ulcers
Endocrine |
PH3 |
Jul 2026 early — Tier 2 timing |
50 |
57% |
Open |
| 424 |
Biogen, Inc. MOR202 · Immunoglobulin A (IgA) Nephropathy (Berger's Disease)
Renal RARE |
PH3 |
Jun 2027 too early — 30+ mo out |
50 |
48% |
Dana |
| 425 |
Veru Inc. Ostarine · HR+/HER2- Breast Cancer
Oncology |
PH3 |
Apr 2026 slightly early |
50 |
44% |
Open |
| 426 |
BeOne Medicines Ltd. BGB-16673 · Non-Hodgkin's Lymphoma (NHL)
Oncology |
PH3 |
Jun 2026 slightly early |
50 |
44% |
Steve |
| 427 |
Laekna Therapeutics Shanghai Co. Ltd. LAE002 · HR+/HER2- Breast Cancer
Oncology |
PH3 |
Jun 2026 slightly early |
50 |
44% |
Open |
| 428 |
Sorrento Therapeutics, Inc. Semdexa · Chronic Pain
Neurology |
PH3 |
Jul 2026 early — Tier 2 timing |
50 |
56% |
Open |
| 429 |
Photocure ASA Cevira · Cervical Dysplasia
Oncology |
PH3 |
Jul 2026 early — Tier 2 timing |
50 |
44% |
Open |
| 430 |
BioNTech SE DB-1303 · HR+/HER2- Breast Cancer
Oncology |
PH3 |
Dec 2026 early — Tier 2 timing |
50 |
44% |
Dana |
| 431 |
BioNTech SE DB-1303 · HR+/HER2- Breast Cancer
Oncology |
PH3 |
Dec 2026 early — Tier 2 timing |
50 |
44% |
Dana |
| 432 |
BioNTech SE pumitamig · Triple-Negative Breast Cancer (TNBC)
Oncology |
PH3 |
Dec 2026 early — Tier 2 timing |
50 |
44% |
Dana |
| 433 |
Immatics N.V. Anzu-cel · Melanoma
Oncology |
PH3 |
Dec 2026 early — Tier 2 timing |
50 |
44% |
Open |
| 434 |
Immunocore, Ltd. Kimmtrak · Melanoma
Oncology |
PH3 |
Dec 2026 early — Tier 2 timing |
50 |
44% |
Amy |
| 435 |
Pfizer Inc. SSGJ-707 · Non-Small Cell Lung Cancer (NSCLC)
Oncology |
PH3 |
Dec 2026 early — Tier 2 timing |
50 |
44% |
Amy |
| 436 |
Pfizer Inc. Sigvotatug Vedotin · Non-Small Cell Lung Cancer (NSCLC)
Oncology |
PH3 |
Dec 2026 early — Tier 2 timing |
50 |
44% |
Amy |
| 437 |
Roche Holding AG Tecentriq · Triple-Negative Breast Cancer (TNBC)
Oncology |
PH3 |
Dec 2026 early — Tier 2 timing |
50 |
44% |
Amy |
| 438 |
Roche Holding AG Tecentriq · Triple-Negative Breast Cancer (TNBC)
Oncology |
PH3 |
Dec 2026 early — Tier 2 timing |
50 |
44% |
Amy |
| 439 |
BioNumerik Pharmaceuticals, Inc. Tavocept · Non-Small Cell Lung Cancer (NSCLC)
Oncology |
PH3 |
Mar 2027 early — Tier 2 timing |
50 |
44% |
Open |
| 440 |
Xenon Pharmaceuticals, Inc. Azetukalner · Partial / Focal Seizures (Epilepsy)
Neurology |
PH3 |
Apr 2026 slightly early |
50 |
54% |
Open |
| 441 |
Eli Lilly and Company Mounjaro · Chronic Heart Failure - Preserved Ejection Fraction (Chronic HFpEF)
Cardiovascular |
PH3 |
Aug 2026 early — Tier 2 timing |
50 |
55% |
Open |
| 442 |
Tarsier Pharma, Ltd Dazdotuftide (eye drops) · Uveitis (Ophthalmology)
Ophthalmology RARE |
PH3 |
Mar 2027 early — Tier 2 timing |
50 |
50% |
Open |
| 443 |
Roche Holding AG astegolimab · Chronic Obstructive Pulmonary Disease (COPD)
Respiratory |
NDA/BLA |
Dec 2026 slightly early |
50 |
58% |
Amy |
| 444 |
Novartis AG zigakibart · Immunoglobulin A (IgA) Nephropathy (Berger's Disease)
Renal RARE |
PH3 |
Aug 2027 too early — 30+ mo out |
50 |
46% |
Dana |
| 445 |
NewAmsterdam Pharma BV obicetrapib · Dyslipidemia / Hypercholesterolemia
Cardiovascular |
PH3 |
Jun 2026 slightly early |
50 |
53% |
Steve |
| 446 |
ImmunityBio Inc. Anktiva · Non-Small Cell Lung Cancer (NSCLC)
Oncology |
PH3 |
Jun 2027 too early — 30+ mo out |
49 |
99% |
Open |
| 447 |
Roche Holding AG RG7845 · Multiple Sclerosis (MS)
Neurology |
NDA/BLA |
Dec 2026 slightly early |
49 |
52% |
Amy |
| 448 |
Roche Holding AG RG7845 · Multiple Sclerosis (MS)
Neurology |
PH3 |
Jun 2026 slightly early |
49 |
52% |
Amy |
| 449 |
Eli Lilly and Company Ixo-vec · Wet Age-Related Macular Degeneration (Wet AMD) (Ophthalmology)
Ophthalmology |
PH3 |
Jul 2026 early — Tier 2 timing |
49 |
52% |
Open |
| 450 |
Annexon, Inc. ANX007 · Dry Age-Related Macular Degeneration (Dry AMD)/Geographic Atrophy (Ophthalmology)
Ophthalmology |
PH3 |
Sep 2026 early — Tier 2 timing |
49 |
52% |
Open |
| 451 |
Acadia Pharmaceuticals Inc. ACP-204 · Neuropsychiatric Symptoms in Alzheimer’s Disease
Psychiatry |
PH3 |
Mar 2026 slightly early |
49 |
51% |
Steve |
| 452 |
Kowa Company, Ltd. Glanatec · Other Ophthalmological Indications (Ophthalmology)
Ophthalmology |
PH3 |
Mar 2026 slightly early |
49 |
51% |
Open |
| 453 |
Krystal Biotech, Inc. KB803 · Ocular Pain and/or Inflammation (Ophthalmology)
Ophthalmology |
PH3 |
Jun 2026 slightly early |
49 |
51% |
Dana |
| 454 |
InnoCare Pharma Ltd. Hibruka · Multiple Sclerosis (MS)
Neurology |
PH3 |
Mar 2026 slightly early |
49 |
50% |
Open |
| 455 |
InnoCare Pharma Ltd. Hibruka · Multiple Sclerosis (MS)
Neurology |
PH3 |
Mar 2026 slightly early |
49 |
50% |
Open |
| 456 |
Palatin Technologies, Inc. PL9643 · Dry Eye (Ophthalmology)
Ophthalmology |
PH3 |
Jun 2026 slightly early |
49 |
50% |
Open |
| 457 |
Roche Holding AG Enspryng · Thyroid Eye Disease (TED)
Ophthalmology |
PH3 |
Jul 2026 early — Tier 2 timing |
49 |
51% |
Amy |
| 458 |
Regeneron Pharmaceuticals, Inc. Veopoz · Dry Age-Related Macular Degeneration (Dry AMD)/Geographic Atrophy (Ophthalmology)
Ophthalmology |
PH3 |
Dec 2026 early — Tier 2 timing |
49 |
51% |
Dana |
| 459 |
Regeneron Pharmaceuticals, Inc. cemdisiran · Dry Age-Related Macular Degeneration (Dry AMD)/Geographic Atrophy (Ophthalmology)
Ophthalmology |
PH3 |
Dec 2026 early — Tier 2 timing |
49 |
51% |
Dana |
| 460 |
Roche Holding AG Enspryng · Thyroid Eye Disease (TED)
Ophthalmology |
PH3 |
Dec 2026 early — Tier 2 timing |
49 |
51% |
Amy |
| 461 |
Roche Holding AG Enspryng · Thyroid Eye Disease (TED)
Ophthalmology |
PH3 |
Dec 2026 early — Tier 2 timing |
49 |
51% |
Amy |
| 462 |
Roche Holding AG Enspryng · Thyroid Eye Disease (TED)
Ophthalmology |
PH3 |
Dec 2026 early — Tier 2 timing |
49 |
51% |
Amy |
| 463 |
Kodiak Sciences Inc. KSI-301 · Wet Age-Related Macular Degeneration (Wet AMD) (Ophthalmology)
Ophthalmology |
PH3 |
Mar 2027 early — Tier 2 timing |
49 |
51% |
Amy |
| 464 |
Roche Holding AG Tecentriq · Prostate Cancer
Oncology |
PH3 |
Jul 2026 early — Tier 2 timing |
49 |
39% |
Amy |
| 465 |
DiaMedica Therapeutics Inc. DM199 · Ischemic Stroke
Cardiovascular |
PH3 |
Jul 2026 early — Tier 2 timing |
49 |
49% |
Amy |
| 466 |
SERB Pharmaceuticals bentracimab · Drug Toxicity
Not Specified |
PDUFA |
Sep 2026 launching <6 mo — conversa |
48 |
94% |
Open |
| 467 |
Cerevance Inc. CVN424 · Parkinson's Disease (PD)
Neurology |
PH3 |
Jun 2026 slightly early |
48 |
47% |
Open |
| 468 |
Praxis Precision Medicines, Inc. PRAX-944 · Essential Tremor
Neurology RARE |
NDA/BLA |
Aug 2027 early — Tier 2 timing |
48 |
42% |
Dana |
| 469 |
Praxis Precision Medicines, Inc. PRAX-628 · Partial / Focal Seizures (Epilepsy)
Neurology |
PH3 |
Jun 2026 slightly early |
48 |
46% |
Dana |
| 470 |
Praxis Precision Medicines, Inc. PRAX-628 · Partial / Focal Seizures (Epilepsy)
Neurology |
PH3 |
Jun 2026 slightly early |
48 |
46% |
Dana |
| 471 |
Novartis AG pelacarsen · Dyslipidemia / Hypercholesterolemia
Cardiovascular |
PH3 |
Dec 2026 early — Tier 2 timing |
48 |
47% |
Dana |
| 472 |
Novartis AG pelacarsen · Dyslipidemia / Hypercholesterolemia
Cardiovascular |
PH3 |
Dec 2026 early — Tier 2 timing |
48 |
47% |
Dana |
| 473 |
AriBio Co., Ltd. AR1001 · Alzheimer's Disease (AD)
Neurology |
PH3 |
Jun 2026 slightly early |
48 |
45% |
Open |
| 474 |
Shanghai CureGene Pharmaceutical Co., Ltd. CG-0255 · Acute Coronary Syndrome (ACS)
Cardiovascular |
PH3 |
Aug 2026 early — Tier 2 timing |
48 |
46% |
Open |
| 475 |
Grunenthal GmbH resiniferatoxin (RTX) · Osteoarthritis Pain
Neurology |
PH3 |
Dec 2026 early — Tier 2 timing |
48 |
46% |
Open |
| 476 |
Grunenthal GmbH resiniferatoxin (RTX) · Osteoarthritis Pain
Neurology |
PH3 |
Dec 2026 early — Tier 2 timing |
48 |
46% |
Open |
| 477 |
Grunenthal GmbH resiniferatoxin (RTX) · Osteoarthritis Pain
Neurology |
PH3 |
Dec 2026 early — Tier 2 timing |
48 |
46% |
Open |
| 478 |
Ipsen SA Dysport · Migraine and Other Headaches
Neurology |
PH3 |
Dec 2026 early — Tier 2 timing |
48 |
46% |
Steve |
| 479 |
Ipsen SA Dysport · Migraine and Other Headaches
Neurology |
PH3 |
Dec 2026 early — Tier 2 timing |
48 |
46% |
Steve |
| 480 |
Lantheus Holdings, Inc. [18F]PI-2620 · Alzheimer's Disease - Imaging
Neurology |
PH3 |
Dec 2026 early — Tier 2 timing |
48 |
46% |
Dana |
| 481 |
Meilleur Technologies, Inc. NAV4694 · Alzheimer's Disease - Imaging
Neurology |
PH3 |
Dec 2026 early — Tier 2 timing |
48 |
46% |
Open |
| 482 |
Renibus Therapeutics Inc. RBT-1 · Coronary Artery Bypass Graft (CABG)
Cardiovascular |
PH3 |
Dec 2026 early — Tier 2 timing |
48 |
46% |
Steve |
| 483 |
Stealth BioTherapeutics Inc. Forzinity · Dry Age-Related Macular Degeneration (Dry AMD)/Geographic Atrophy (Ophthalmology)
Ophthalmology |
PH3 |
Dec 2026 early — Tier 2 timing |
48 |
46% |
Open |
| 484 |
Renibus Therapeutics Inc. RBT-1 · Cardiac Valve Surgery
Cardiovascular |
PH3 |
Mar 2027 early — Tier 2 timing |
48 |
46% |
Steve |